why are things like pc optimizer pro allowed

If these functionalities, and thus the resulting reaction between them, are bio-orthogonal, the new ligation has the potential to be applied to biologically relevant molecules or environments 3. Small complementary chemical functionalities that allow for selective and specific formation of a stable product are ideal candidates for the development of new ligation methodologies 1, 2. This convenient methodology was further implemented on plastic and glass surfaces to realize self-addressable covalent constructs. The reaction was applied to the formation of PNA-PNA adducts, DNA- and RNA-templated ligations, and for the formation of peptide-peptide adducts in solution. This bio-orthogonal ligation, which proceeds under physiological conditions, does not require any stimulus or trigger and leads to the formation of a pyridazinium adduct that demonstrates excellent stability under harsh conditions (24 h at 90 ☌). We here report on a proximity-induced ligation reaction that relies on a stable 2,5-dione, that can be conveniently generated under acidic conditions from a 2,5-dialkylfuran building block, and hydrazine nucleophiles. However, most of the available strategies rely on highly reactive species that require careful handling, or on the activation of pro-reactive functional groups. Ligation methodologies featuring bio-orthogonal units and leading to the formation of a stable adduct are the ideal candidates for being applied in a biological context.

Why are things like pc optimizer pro allowed